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Management of Women at High Risk for Gynecologic Cancers and overexpression, a point mutation, or by translocation and exposure to a promoter sequence that results in overexpression. HER-2/neu is an example of an oncogene that is found in a variety of cancers, but it has clinical relevance primarily in breast cancer.1 Tumor suppressor genes are recessive genes that encode factors that inhibit cell growth by inhibiting cellular division, initiating apoptosis (cell death) or promoting DNA repair. Loss of both alleles is necessary to promote malignant transformation. The two-hit mechanism applies to both inherited and acquired cancers. In hereditary cancers, one mutated allele may be inherited and the second acquired over time, while in sporadic cancers, both mutations are acquired. Similarly to oncogenes, tumor suppressor genes may be mutated by point mutations and deletions or additions of nucleotides. Examples of tumor suppressor genes include p53, p16, and the retinoblastoma (Rb) gene.1 Mismatch repair genes correct DNA damage that occurs during normal DNA replication. A malfunction in one of these genes can result in a buildup of errors, some of which may ultimately affect the genes involved in cell regulation. Some inherited cancers are a result of germline mutations in mismatch repair genes. One example is hereditary nonpolyposis colorectal cancer (HNPCC), which causes an increased risk of colorectal and endometrial cancer, in addition to several other cancers of the gastrointestinal (gastric and biliary) and reproductive tracts, including ovarian cancer.2

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7 contains scenarios from control, surveillance, monitoring and transportation domains along with their typical parameters, requirements, roles, traf c, threads, legal/economic issues that best characterize the research performed in the eld Finally, section 28 summarizes the outcome of the study to be used as a measurement for application domain s importance and acting as a means of weighting con icting requirements..

In the previous procedure, the existing backup-current directory replaces the backup-old directory, deleting the two-week-old full backup with last-week s full backup. When the new full backup is run with rsync using the --link-dest option,

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$ ps -ejH PID PGID 1 1 2 1 Show process hierarchy with process/session IDs SID TTY TIME CMD 1 00:00:01 init 1 00:00:00 migration/0

jk g (wk (x k )),

number of entities, the mobile phone (actually the SIM , see below) and the home network The second constraint is that long distance signalling should be minimised It was therefore not acceptable that the authentication process should involve the home operator for every call made by a roaming subscriber of that operator Ki should not even be known by the user themselves either, as this would allow the selfcloning of phones, and subsequent denial of the calls made by the cloned phones that had already occurred in analogue networks A secure module within the phone, that could be programmed by or under the control of the operator, and in which Ki was stored and all operations involving Ki carried out, was therefore required A smart card was the obvious choice for such a security module, and the GSM Subscriber Identity Module (SIM) was born (see 13 for details).

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CAUTION: Never try to use any of the sample legal documents on your own. They are for illustration only and do not necessarily contain all the terms you need. It is most important to note that the laws differ from state to state so that you always need a local attorney to assist with a real estate closing.

The Ki is stored and used in the SIM and not in the terminal (or to use GSM terminology, the Mobile Equipment (ME)) The security architecture is now described, in two stages Ki in the home operator is held in the operator Authentication Centre (AuC) (GSM Phase 1 did allow the Ki to be sent from the AuC to a VLR for use there, but this was only allowed for VLRs in the same PLMN as the AuC, the speci cation advised against the option, and the option was dropped in GSM Phase 2) The AuC generates a random number, RAND for each subscriber.

(1.43)

Random challenges are commonly used in security protocols to guarantee that a particular run of the protocol is fresh and entirely new and that an impostor who has captured some parameters from a previous run of the protocol cannot masquerade as the genuine subscriber or operator or interfere (either actively or passively) with the current run of the protocol As shown in Figure 151, for a particular subscriber, each RAND is passed as a parameter, along with the Ki for that subscriber, through an algorithm named A3 A3 produces as an output, an expected response, XRES The use of a challenge-response mechanism was not a proposal of a particular delegate in SEG Once it was decided that a secret key mechanism would be used, a challenge-response mechanism was the obvious choice..

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